The University Research Center (U.R.C.) of the Ionian University was established in 2018 and was renamed the University Center for Research and Innovation (UCRI) pursuant to Article 462 of Law 4957/2022. It operates as a distinct academic unit.

The mission of the UCRI is to develop basic, applied, and interdisciplinary research within the framework of the National Strategy for Research, Technological Development and Innovation and the National Smart Specialization Strategy. It also aims to promote interdisciplinary knowledge, technology, and innovation; advance the humanities and the arts; ensure effective interaction between education and research; train and utilize research personnel; and address the educational, research, social, cultural, and developmental needs of the country, while contributing to economic development at the local, national, European, and international levels.